Case Report: E-cadherin and Vimentin expression in advanced-stage pancreatic ductal adenocarcinoma tissue and circulating tumor cells: preliminary results from a pilot study - Scorecard - MDSpire

Case Report: E-cadherin and Vimentin expression in advanced-stage pancreatic ductal adenocarcinoma tissue and circulating tumor cells: preliminary results from a pilot study

  • By

  • Maria Cristina Rapanotti

  • Maria Giovanna Scioli

  • Alessandro Moscardelli

  • Edoardo Troncone

  • Elisa Cugini

  • Tara Mayte Suarez Viguria

  • Lorena Vergilii

  • Martina Puzzuoli

  • Silvia Anzillotti

  • Sonia Terriaca

  • Tonia Cenci

  • Eleonora Muzzi

  • Elena De Cristofaro

  • Luca Savino

  • Luca Toti

  • Anastasia De Luca

  • Amedeo Ferlosio

  • Giovanna Del Vecchio Blanco

  • Augusto Orlandi

  • May 29, 2026

  • 0 min

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Clinical Scorecard: Preliminary Findings from a Pilot Study on E-cadherin and Vimentin Expression in Advanced Pancreatic Ductal Adenocarcinoma Tissues and Circulating Tumor Cells

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPatients with advanced PDAC.
Care Setting

Key Highlights

  • E-cadherin expression absent in 3 G3 PDAC cases.
  • 72.7% of samples showed low-to-moderate E-cadherin positivity.
  • Vimentin expressed in 81.8% of CTC samples.
  • Distinct EMT expression observed between primary tumors and CTCs.
  • Study emphasizes the role of mesenchymal-invasive profiles in PDAC.

Guideline-Based Recommendations

Diagnosis

    Management

    • Identify biomarkers for aggressive disease to guide treatment choices, including specific therapies.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Potential for personalized cancer management through CTC characterization, including specific treatment options.

        Clinical Best Practices

        • Prioritize EUS-FNB for tissue acquisition in suspected PDAC.
        • Combine epithelial and mesenchymal biomarkers for CTC capture, detailing specific biomarkers.

        Related Resources & Content

        Original Source(s)

        Case Report: E-cadherin and Vimentin expression in advanced-stage pancreatic ductal adenocarcinoma tissue and circulating tumor cells: preliminary results from a pilot study

        • by Maria Cristina Rapanotti, Maria Giovanna Scioli, Alessandro Moscardelli, Edoardo Troncone, Elisa Cugini, Tara Mayte Suarez Viguria, Lorena Vergilii, Martina Puzzuoli, Silvia Anzillotti, Sonia Terriaca, Tonia Cenci, Eleonora Muzzi, Elena De Cristofaro, Luca Savino, Luca Toti, Anastasia De Luca, Amedeo Ferlosio, Giovanna Del Vecchio Blanco, Augusto Orlandi

        • May 29, 2026

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