COVID-19 mRNA vaccines: a prospective outlook from technological innovation to clinical practice
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By
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Junqi Ma
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Huoying Chen
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Yunyi He
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Yuye Huang
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Xianlong Duan
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Qiliang Liu
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Zheng Liu
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Hongbo Liu
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June 4, 2026
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Clinical Scorecard: Future Perspectives on COVID-19 mRNA Vaccines: From Technological Advancements to Clinical Implementation
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | General population, including pregnant and lactating women, older adults, and children. |
| Care Setting | |
Key Highlights
- Vaccine effectiveness declined against infection with the emergence of Omicron variants.
- Post-authorization surveillance indicates a favorable safety profile with mostly mild adverse events.
Guideline-Based Recommendations
Diagnosis
Management
- Implement booster doses targeting emerging variants.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Vaccination provides protection against severe outcomes.
Clinical Best Practices
- Ensure clear communication about the distinction between protection against infection and severe outcomes.
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