Cognitive impairment and associated factors in elderly patients with schizophrenia: a retrospective observational study with phenotype analysis - Scorecard - MDSpire
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Cognitive impairment and associated factors in elderly patients with schizophrenia: a retrospective observational study with phenotype analysis
Clinical Scorecard: Cognitive Dysfunction and Contributing Factors in Older Adults with Schizophrenia: A Retrospective Observational Study with Phenotypic Analysis
At a Glance
Category
Detail
Condition
Cognitive impairment in elderly patients with schizophrenia
Key Mechanisms
Influenced by social support, functional independence, diabetes, and chronic comorbidities
Target Population
Elderly patients (≥60 years) with schizophrenia
Care Setting
Tertiary psychiatric hospital inpatient units
Key Highlights
Prevalence of cognitive impairment is 47.7% among elderly patients with schizophrenia.
Higher social support and functional independence are associated with lower odds of cognitive impairment.
Diabetes mellitus is linked to increased odds of cognitive impairment.
Three cognitive and psychosocial phenotypes identified: optimal functioning, mild-to-moderate impairment, and severe impairment.
Good classification performance of the model with an accuracy of 96.6%.
Guideline-Based Recommendations
Diagnosis
Use Montreal Cognitive Assessment (MoCA) for cognitive impairment evaluation.
Management
Integrate cognitive rehabilitation, chronic disease management, and social support in care plans.
Monitoring & Follow-up
Regular assessment of cognitive function and psychosocial factors.
Risks
Increased risk of poor medication adherence and accidents due to cognitive impairment.
Patient & Prescribing Data
149 elderly inpatients with schizophrenia
Focus on multidimensional care models to improve outcomes.
Clinical Best Practices
Assess cognitive and psychosocial factors regularly.
