Prediction of anastomotic leakage after esophagectomy for esophageal cancer: a nomogram study integrating systemic inflammation indices and clinical factors
By
Ruonan Tan
Lili Guo
Saitian Li
Weiran Huang
Hang Zhang
Tongtong Gu
Qian Ba
July 14, 2026
Clinical Scorecard: Forecasting Anastomotic Leakage Risk Post-Esophagectomy in Esophageal Cancer: A Nomogram Incorporating Systemic Inflammatory Markers and Clinical Variables
At a Glance
Category Detail
Condition Anastomotic Leakage (AL) post-esophagectomy Key Mechanisms Systemic inflammatory markers and clinical variables Target Population Esophageal cancer patients undergoing esophagectomy Care Setting Surgical oncology
Key Highlights
Anastomotic leakage is a major complication post-esophagectomy, affecting outcomes. Seven significant predictors of AL identified: age, neoadjuvant radiotherapy, CALLY index, hypertension, NLR, NMR, and PLR. Nomogram developed shows good discrimination (AUC = 0.813) in training set. Moderate predictive accuracy demonstrated in validation cohort (AUC = 0.763). Guideline-Based Recommendations
Diagnosis
AL defined according to the Esophagectomy Complications Consensus Group (ECCG). Management
Utilize predictive model for risk stratification in esophageal cancer patients. Monitoring & Follow-up
Assess systemic inflammatory markers and clinical variables preoperatively. Risks
AL associated with increased mortality, additional surgical interventions, and higher healthcare costs. Patient & Prescribing Data
650 esophageal cancer patients undergoing esophagectomy.
Incorporation of inflammatory-nutritional indices may improve predictive accuracy.
Clinical Best Practices
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