Combined assessment of carotid intima–media thickness and epicardial fat thickness for cardiovascular risk stratification in asymptomatic South Indian adults - Scorecard - MDSpire
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Evaluation of Carotid Intima-Media Thickness and Epicardial Fat Thickness for Cardiovascular Risk Assessment in Asymptomatic Adults from South India

  • By

  • Ramesh Sankaran

  • Dolly Agarwal

  • Rahul Mittal

  • Shankar Srinivasan

  • Nagendra Boopathy Senguttuvan

  • Alex Karev

  • Sadhanandham Shanmugasundaram

  • Balasubramaniyan Jayanthi Venkata

  • Vinod Kumar Balakrishnan

  • Preetam Krishnamurthy

  • Sadagopan Thanikachalam

  • Murthy Jayanthi Satyanarayana

  • September 3, 2026

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Clinical Scorecard: Evaluation of Carotid Intima-Media Thickness and Epicardial Fat Thickness for Cardiovascular Risk Assessment in Asymptomatic Adults from South India

At a Glance

CategoryDetail
ConditionCardiovascular Risk Assessment
Key MechanismsCarotid intima-media thickness (cIMT) and epicardial fat thickness (EFT) as non-invasive imaging markers linked to cardiovascular risk.
Target PopulationAsymptomatic adults aged ≥18 years with or without cardiovascular risk factors.
Care SettingRoutine cardiovascular health evaluations.

Key Highlights

  • Participants with cardiovascular risk factors had significantly higher cIMT and EFT compared to controls.
  • Abnormal cIMT prevalence increased with age, from 2.2% in those under 40 to 28.0% in those over 60.
  • Hypertension, diabetes mellitus, and dyslipidaemia were significantly associated with increased cIMT and EFT.
  • Mean left cIMT was modestly but significantly higher than mean right cIMT.
  • Cumulative cardiovascular risk-factor burden correlated with progressively higher cIMT and EFT values.

Guideline-Based Recommendations

Diagnosis

  • Utilize carotid ultrasonography for cIMT measurement.
  • Employ transthoracic echocardiography for EFT assessment.

Management

  • Incorporate cIMT and EFT in cardiovascular risk stratification alongside traditional risk factors.

Monitoring & Follow-up

  • Monitor changes in cIMT and EFT in patients with known cardiovascular risk factors.

Risks

  • Increased cIMT and EFT are associated with higher cardiovascular risk and potential future events.

Patient & Prescribing Data

Asymptomatic adults undergoing routine cardiovascular health assessments.

Consider the role of cIMT and EFT in identifying subclinical atherosclerosis for preventive interventions.

Clinical Best Practices

  • Use non-invasive imaging markers to enhance cardiovascular risk assessment.
  • Regularly evaluate asymptomatic adults for cardiovascular risk factors.

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