Phase entropy of gated SPECT-MPI for predicting major adverse cardiovascular events: incremental prognostic value beyond perfusion and function - Scorecard - MDSpire
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Phase entropy of gated SPECT-MPI for predicting major adverse cardiovascular events: incremental prognostic value beyond perfusion and function
Clinical Scorecard: Evaluating Phase Entropy from Gated SPECT-MPI as a Predictor of Major Adverse Cardiovascular Events: Added Prognostic Insights Beyond Perfusion and Function
At a Glance
Category
Detail
Condition
Coronary artery disease
Key Mechanisms
Phase entropy reflects spatiotemporal heterogeneity of myocardial contraction and quantifies left ventricular mechanical synchrony.
Target Population
Patients with coronary artery disease
Care Setting
Cardiovascular imaging and risk stratification
Key Highlights
Phase entropy ≤31% or >53% correlates with reduced survival.
Phase entropy independently predicts major adverse cardiovascular events (MACE).
Addition of phase entropy to models including total perfusion deficit (TPD) and left ventricular ejection fraction (LVEF) improves MACE prediction.
Guideline-Based Recommendations
Diagnosis
Use phase entropy as a biomarker for assessing cardiovascular risk in patients with coronary artery disease.
Management
Consider intensified clinical monitoring for patients with abnormal phase entropy values.
Monitoring & Follow-up
Regular assessment of phase entropy in patients undergoing gated SPECT-MPI.
Risks
Patients with abnormal phase entropy values are at higher risk for major adverse cardiovascular events.
Patient & Prescribing Data
Coronary artery disease patients, median age 62.0 years, 66.2% male.
Phase entropy provides incremental prognostic value beyond conventional predictors.
Clinical Best Practices
Incorporate phase entropy analysis in routine gated SPECT-MPI evaluations.
Utilize phase entropy thresholds for risk stratification and management decisions.
