Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation - Scorecard - MDSpire

Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation

  • By

  • Kaiyuan Zhang

  • Yuqing Huang

  • Yuan Wu

  • Zhitao Yang

  • Fangyu Luo

  • Yu Han

  • Lan Zheng

  • Lingling Lv

  • June 29, 2026

  • 0 min

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Clinical Scorecard: Baihe Gujin Decoction Enhances Antioxidant Defense and Metabolic Reprogramming in Sepsis-Induced Acute Lung Injury via Nrf2/GPX4 and PPARα Pathways: A Multi-Omics Study

At a Glance

CategoryDetail
ConditionSepsis-induced acute lung injury (ALI)
Key MechanismsActivation of Nrf2/GPX4 antioxidant response and PPARα/CPT1A metabolic remodeling
Target PopulationPatients with sepsis-induced acute lung injury
Care SettingClinical research and traditional Chinese medicine application

Key Highlights

  • BHGJD significantly ameliorated CLP-induced ALI.
  • Enhanced antioxidant defense through Nrf2/GPX4 pathway.
  • Promoted fatty acid utilization via PPARα/CPT1A pathway.
  • Reduced inflammatory cytokine levels in serum.
  • Integrated multi-omics analysis revealed interconnected protective mechanisms.

Guideline-Based Recommendations

Diagnosis

  • Assessment of sepsis-induced acute lung injury through clinical and histopathological evaluation.

Management

  • Consider Baihe Gujin decoction as an adjunctive therapy for sepsis-induced ALI.

Monitoring & Follow-up

  • Monitor inflammatory cytokine levels and oxidative stress markers.

Risks

  • Potential for high mortality rates in untreated sepsis-induced ALI.

Patient & Prescribing Data

Patients experiencing sepsis-induced acute lung injury.

BHGJD may enhance antioxidant defenses and metabolic reprogramming.

Clinical Best Practices

  • Utilize multi-omics approaches for understanding treatment mechanisms.
  • Integrate traditional Chinese medicine with conventional therapies.

Related Resources & Content

Original Source(s)

Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2/GPX4-mediated antioxidant defense and PPARα-driven metabolic reprogramming: a multi-omics investigation

  • by Kaiyuan Zhang, Yuqing Huang, Yuan Wu, Zhitao Yang, Fangyu Luo, Yu Han, Lan Zheng, Lingling Lv

  • June 29, 2026

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