Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesis - Scorecard - MDSpire
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Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesis
Clinical Scorecard: Impaired Arsenic Methylation and Comprehensive Proteomic Alterations in Human Keratinocytes During Skin Cancer Development Induced by Arsenic
At a Glance
Category
Detail
Condition
Skin Cancer
Key Mechanisms
Chronic exposure to inorganic arsenic leads to malignant transformation of human keratinocytes.
Target Population
Individuals exposed to inorganic arsenic in drinking water.
Care Setting
Preclinical research and molecular biology studies.
Key Highlights
Chronic exposure to inorganic arsenic is linked to non-melanoma skin cancer.
HaCaT cells serve as a model for studying arsenic-induced cutaneous squamous cell carcinoma.
Differential protein expression changes occur during arsenic-induced malignant transformation.
Arsenic methylation status may influence carcinogenic outcomes in keratinocytes.
Longitudinal proteomic profiling is essential for understanding the mechanisms of arsenic-induced carcinogenesis.
Guideline-Based Recommendations
Diagnosis
Monitor for skin cancer in populations with known arsenic exposure.
Management
Implement strategies to reduce arsenic exposure in drinking water.
Monitoring & Follow-up
Conduct regular skin examinations for early detection of skin cancer.
Risks
Increased risk of skin cancer associated with chronic arsenic exposure.
Patient & Prescribing Data
Individuals with chronic arsenic exposure.
Understanding the molecular pathways may inform targeted therapies for arsenic-induced skin cancer.
Clinical Best Practices
Utilize preclinical models to study the effects of arsenic on skin carcinogenesis.
Assess arsenic methylation status in keratinocyte studies.
by Alexandra N. Nail, Mayukh Banerjee, Manting Xu, Caitlin H. Reynolds, Miroslav Stýblo, Peter H. Cable, Daniel W. Wilkey, Michael L. Merchant, Ana P. Ferragut Cardoso, Shelia D. Thomas, J. Christopher States
