Population-Level Outcomes for Screening Program Cancers in First Nations People in Ontario, Canada
By
Amanda J. Sheppard
Rinku Sutradhar
Ning Liu
Alethea Kewayosh
Sayna Leylachian
Laura Senese
Andrea Ianni
Sarah Hyett
Anna M. Chiarelli
Rachel Kupets
C. Martin Tammemägi
Jill Tinmouth
July 10, 2026
Clinical Scorecard: Cancer Screening Program Outcomes at the Population Level Among First Nations Communities in Ontario, Canada
At a Glance
Category Detail
Condition Cancer Screening Outcomes
Key Mechanisms Population-based cancer screening programs including breast, cervical, and colon cancer screenings.
Target Population First Nations adults in Ontario with registered status under the Indian Act.
Care Setting Ontario Health cancer screening programs.
Key Highlights
Indigenous peoples in Canada now experience a higher burden of cancer compared to non-Indigenous populations. From 1991 to 2010, First Nations people had higher incidence and lower survival rates for colon and cervical cancers. First Nations females showed increasing incidence of breast cancer with worse survival rates compared to non-Indigenous females. Community engagement highlighted concerns of younger age at cancer diagnosis among First Nations individuals. The study utilized comprehensive datasets to report on cancer incidence, mortality, and survival.
Guideline-Based Recommendations
Diagnosis
Utilize age- and sex-adjusted incidence data for screening program cancers.
Management
Implement community-based research and engagement for better understanding of cancer outcomes.
Monitoring & Follow-up
Track cancer incidence and mortality rates among First Nations populations.
Risks
Consider comorbidity and stage at diagnosis as factors affecting survival rates.
Patient & Prescribing Data
First Nations adults aged 18 years or older in Ontario.
Data indicates a need for improved cancer screening and management strategies tailored to First Nations communities.
Clinical Best Practices
Follow First Nations research principles of ownership, control, access, and possession. Engage Indigenous partners in project design and implementation.
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