Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study
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By
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Gang Liu
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Qiangying Guo
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Jie Xiang
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Zhen Xu
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Suying Chen
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Yanling Xue
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Zhitao Liu
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Huixia Jin
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Shangyi Yu
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Ting Jiao
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Xia Chen
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Zhenzhen Liu
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Xiangying Xi
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Yanhong Li
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Lili Shang
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Jiao Du
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Xianzhong Liu
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Shihui Wei
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June 24, 2026
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Clinical Scorecard: Long-term effectiveness of neural circuit blockade in the management of blepharospasm: a retrospective case series analysis
At a Glance
| Category | Detail |
|---|
| Condition | Blepharospasm |
| Key Mechanisms | Neural circuit blockade (NCB) reduces trigeminal nerve stimulation and orbicularis oculi muscle tension. |
| Target Population | Patients with blepharospasm refractory to standard treatments. |
| Care Setting | Single-centre, retrospective case series analysis. |
Key Highlights
- NCB resulted in 87.5% of patients achieving complete remission postoperatively.
- Significant improvements observed in Shorr grading scale and BFMDRS-M scores.
- No severe local or systemic complications reported.
Guideline-Based Recommendations
Diagnosis
- Diagnosis based on involuntary spasmodic contractions of periorbital muscles.
Management
- Neural circuit blockade (NCB) is recommended for patients refractory to oral medications, botulinum toxin injections, and deep brain stimulation.
Monitoring & Follow-up
- Postoperative follow-up with Shorr grading scale, BFMDRS-M, and BSDI scores.
Risks
- No severe complications such as facial paralysis reported.
Patient & Prescribing Data
570 patients with blepharospasm treated with NCB.
Median follow-up of 51 months demonstrated stable long-term efficacy.
Clinical Best Practices
- Adhere to STROBE guidelines for data authenticity and accuracy.
- Obtain written informed consent from all patients.
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