Case Report: Perifoveal exudative vascular anomalous complex with secondary fundus hemorrhage - Scorecard - MDSpire

Case Report: Perifoveal exudative vascular anomalous complex with secondary fundus hemorrhage

  • By

  • Ziqing Liu

  • Xiaoyan Zhang

  • Xiujuan Du

  • Chunhuan Niu

  • Fang Sha

  • Bo Wen

  • Yane Gao

  • Ying Wen

  • June 4, 2026

  • 0 min

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Clinical Scorecard: Case Study: Perifoveal Exudative Vascular Anomaly Complex Leading to Secondary Fundus Hemorrhage

At a Glance

CategoryDetail
ConditionPerifoveal exudative vascular anomalous complex (PEVAC)
Key MechanismsCharacterized by isolated, circular aneurysmal lesions surrounding the fovea centralis.
Target PopulationOtherwise healthy patients, specifically noted in a 44-year-old Chinese woman.
Care SettingOutpatient clinic

Key Highlights

  • PEVAC can lead to secondary fundus hemorrhage.
  • Diagnosis confirmed through multiple imaging modalities including FFA, ICGA, OCT, and OCTA.
  • Intravitreal anti-VEGF treatment resulted in marked improvement in visual acuity.
  • Menstrual cycle may influence disease progression, though the relationship is unclear.

Guideline-Based Recommendations

Diagnosis

  • Use fundus fluorescein angiography, indocyanine green angiography, optical coherence tomography, and optical coherence tomography angiography for diagnosis.

Management

  • Intravitreal anti-VEGF therapy is recommended for treatment.

Monitoring & Follow-up

  • Regular follow-up to assess visual acuity and changes in retinal lesions.

Risks

  • Laser photocoagulation poses a risk of iatrogenic foveal damage.

Patient & Prescribing Data

A 44-year-old Chinese woman with no significant past medical history.

Intravitreal ranibizumab injections were administered, leading to improvement in visual acuity.

Clinical Best Practices

  • Consider the potential influence of the menstrual cycle on visual acuity in female patients.
  • Prioritize non-invasive treatment options when lesions are near the fovea.

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