Lactate Dehydrogenase-to-Albumin Ratio Predicts 30-Day and 90-Day Mortality in Glucocorticoid-Treated ICU Patients With Pneumonia: A Secondary Analysis of a Multicenter Cohort - Scorecard - MDSpire
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Lactate Dehydrogenase-to-Albumin Ratio Predicts 30-Day and 90-Day Mortality in Glucocorticoid-Treated ICU Patients With Pneumonia: A Secondary Analysis of a Multicenter Cohort
Clinical Scorecard: Lactate Dehydrogenase to Albumin Ratio as a Predictor of 30-Day and 90-Day Mortality in ICU Patients with Pneumonia Undergoing Glucocorticoid Treatment: Insights from a Secondary Analysis of a Multicenter Study
At a Glance
Category
Detail
Condition
Pneumonia in ICU patients receiving glucocorticoids
Key Mechanisms
Lactate dehydrogenase-to-albumin ratio (LAR) reflects cellular injury and nutritional reserve
Target Population
ICU patients with pneumonia undergoing glucocorticoid treatment
Care Setting
Intensive Care Unit (ICU)
Key Highlights
Optimal LAR cutoff for 30-day mortality is 13.39.
High LAR (≥13.39) correlates with increased 30-day (45.8%) and 90-day (51.4%) mortality.
High LAR remains an independent predictor of mortality after multivariable adjustment.
LAR provides significant incremental prognostic value when added to the PSI score.
LAR demonstrates good discrimination with an AUC of approximately 0.74.
Guideline-Based Recommendations
Diagnosis
Utilize LAR as a prognostic tool in pneumonia patients receiving glucocorticoids.
Management
Incorporate LAR into clinical assessments for early risk stratification.
Monitoring & Follow-up
Monitor LAR levels to guide individualized management strategies.
Risks
High LAR is associated with significantly higher mortality rates at 30 and 90 days.
Patient & Prescribing Data
ICU patients with pneumonia on glucocorticoids
LAR is a steroid-resilient biomarker that aids in risk stratification.
Clinical Best Practices
Consider LAR in conjunction with other clinical scores for comprehensive assessment.
Regularly assess LAR to adjust treatment plans based on mortality risk.
Older age, male sex, underweight status, reduced activities of daily living, and mild consciousness disturbance were associated with postextubation pneumonia in elective surgical patients.
