Role of psychological resilience and psychological distress in linking fear of disease progression to quality of life in chronic heart failure: a cross-sectional serial mediation analysis - Scorecard - MDSpire

Role of psychological resilience and psychological distress in linking fear of disease progression to quality of life in chronic heart failure: a cross-sectional serial mediation analysis

  • By

  • Hong Ding

  • Xiaoxia Fang

  • Shixun Li

  • Liyun Miao

  • Xiao Wu

  • May 25, 2026

  • 0 min

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Clinical Scorecard: Influence of Psychological Resilience and Distress on the Relationship Between Fear of Disease Progression and Quality of Life in Chronic Heart Failure: A Cross-Sectional Mediation Study

At a Glance

CategoryDetail
ConditionChronic Heart Failure (CHF)
Key MechanismsFear of disease progression (FoP), psychological resilience, psychological distress
Target PopulationPatients with chronic heart failure
Care SettingInpatient department of a tertiary hospital

Key Highlights

  • Elevated levels of fear of disease progression (FoP) observed in CHF patients.
  • Psychological resilience and distress serve as significant mediators between FoP and quality of life (QoL).
  • FoP negatively impacts QoL directly and indirectly through psychological factors.

Guideline-Based Recommendations

Diagnosis

  • Confirm diagnosis of CHF with left ventricular ejection fraction (LVEF) ≤ 50%.

Management

  • Assess psychological status of patients with CHF to improve resilience and reduce distress.

Monitoring & Follow-up

  • Regularly evaluate QoL and psychological factors in CHF patients.

Risks

  • Increased risk of rehospitalization associated with high levels of FoP.

Patient & Prescribing Data

212 patients with CHF admitted between June 2023 and June 2025.

Psychological resilience can improve QoL by regulating emotional responses.

Clinical Best Practices

  • Implement interventions aimed at enhancing psychological resilience.
  • Address psychological distress to mitigate its impact on QoL.

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