Metagenomic Characterization of Gut Microbiota in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Taxonomic Shifts and Clinical Correlations - Scorecard - MDSpire

Metagenomic Characterization of Gut Microbiota in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Taxonomic Shifts and Clinical Correlations

  • By

  • Fan, Ran

  • Zang, Qifeng

  • Xu, Yan

  • Gao, Ling

  • Zhou, Jun

  • Zang, Yinshan

  • May 28, 2026

  • 0 min

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Clinical Scorecard: Metagenomic Analysis of Gut Microbiota in Patients with Interstitial Lung Disease Linked to Rheumatoid Arthritis: Taxonomic Changes and Clinical Associations

At a Glance

CategoryDetail
ConditionRheumatoid arthritis-associated interstitial lung disease (RA-ILD)
Key MechanismsGut microbiota dysbiosis linked to RA-ILD pathogenesis
Target PopulationPatients with rheumatoid arthritis and interstitial lung disease
Care SettingClinical research setting

Key Highlights

  • Exploratory analysis revealed enrichment of Escherichia/Shigella in RA-ILD patients.
  • Depletion of Roseburia and Ruminococcus observed in RA-ILD compared to RA-non-ILD.
  • Pro-inflammatory genera correlated positively with disease activity.
  • Butyrate-producing genera correlated negatively with disease activity.
  • Random forest classification identified specific taxa as discriminators between groups.

Guideline-Based Recommendations

Diagnosis

  • Limited diagnostic biomarkers for RA-ILD.

Management

  • Further validation of identified taxa as candidate biomarkers in larger cohorts.

Monitoring & Follow-up

  • Correlation of gut microbiota changes with systemic inflammation.

Risks

  • Potential for gut microbiota alterations to influence RA-ILD pathogenesis.

Patient & Prescribing Data

41 participants including RA-ILD patients, RA-non-ILD patients, and healthy controls.

Specific gut microbial alterations may inform future therapeutic strategies.

Clinical Best Practices

  • Consider gut microbiota profiling in RA-ILD research.
  • Monitor systemic inflammation in relation to gut microbiota changes.

Related Resources & Content

    Original Source(s)

    Metagenomic Characterization of Gut Microbiota in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Taxonomic Shifts and Clinical Correlations

    • by Fan, Ran , Zang, Qifeng , Xu, Yan , Gao, Ling , Zhou, Jun , Zang, Yinshan

    • May 28, 2026

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