The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway - Scorecard - MDSpire

The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

  • By

  • Juan Li

  • Yingying Huang

  • Chaoping Ma

  • Guoxiang Liu

  • Caiting Chu

  • Jiameng Chen

  • Huiqi Wang

  • Jiawei Ye

  • Min Jiao

  • Yiran Guo

  • Jiyuan Zhang

  • Yuxin Leng

  • Chengjin Gao

  • April 22, 2026

  • 0 min

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Clinical Scorecard: The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPatients with sepsis, including both adults and children.
Care Setting

Key Highlights

  • IFI27 may have therapeutic implications in enhancing Treg function.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Monitor IL-10 levels and Treg populations in sepsis patients at regular intervals (e.g., weekly).

      Risks

        Patient & Prescribing Data

        Potential therapeutic strategies may involve modulation of IFI27 to restore Treg function; currently under investigation.

        Clinical Best Practices

        • Educate patients on the importance of monitoring and managing sepsis.

        References

        Original Source(s)

        The Role of IFI27 in Modulating Regulatory T Cell Activity Contributes to Lung Injury in Sepsis Through IL-10/STAT3 Pathway

        • by Juan Li, Yingying Huang, Chaoping Ma, Guoxiang Liu, Caiting Chu, Jiameng Chen, Huiqi Wang, Jiawei Ye, Min Jiao, Yiran Guo, Jiyuan Zhang, Yuxin Leng, Chengjin Gao

        • April 22, 2026

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