Survival without major morbidity in very preterm infants (<32 weeks’ gestation): prevalence, temporal trends, and associated factors in a single-center retrospective cohort - Scorecard - MDSpire
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Outcomes of Very Preterm Infants (<32 Weeks’ Gestation) Surviving Without Major Morbidity: A Single-Center Retrospective Study on Prevalence, Trends, and Contributing Factors
Clinical Scorecard: Outcomes of Very Preterm Infants (<32 Weeks’ Gestation) Surviving Without Major Morbidity: A Single-Center Retrospective Study on Prevalence, Trends, and Contributing Factors
At a Glance
Category
Detail
Condition
Very Preterm Infants (VPIs)
Key Mechanisms
Survival without major morbidity (SWMM) is influenced by gestational age, birth weight, sex, surfactant doses, and Apgar scores.
Target Population
Infants born at <32 weeks’ gestation admitted to NICU.
Care Setting
Neonatal Intensive Care Unit (NICU)
Key Highlights
Among 1,094 VPIs receiving complete care, 95.5% survived, but only 59.9% achieved SWMM.
SWMM rates showed a decreasing trend over time despite stable survival rates.
Each additional week of gestational age significantly increased the odds of SWMM.
Male sex and lower Apgar scores were associated with decreased odds of SWMM.
DAMA occurred in 6.7% of VPIs, with decreasing frequency as gestational age increased.
Guideline-Based Recommendations
Diagnosis
SWMM defined as survival without bronchopulmonary dysplasia (BPD), severe brain injury, necrotizing enterocolitis (NEC) stage II or higher, late-onset sepsis (LOS), or severe retinopathy of prematurity (ROP).
Management
Implement GA-stratified care and optimized perinatal stabilization.
Monitoring & Follow-up
Track temporal trends in SWMM and associated factors to inform quality improvement.
Risks
Increased risk of BPD and severe ROP over time among surviving VPIs.
Patient & Prescribing Data
Very preterm infants (<32 weeks’ gestation) admitted to NICU.
Surfactant therapy and careful monitoring of Apgar scores are critical in managing VPIs.
Clinical Best Practices
Enhance early respiratory management for VPIs.
Reduce the incidence of DAMA through improved parental counseling.
