Gut barrier-microbiota crosstalk in sepsis: from pathogenesis to potential therapies
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By
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Lingshuai Meng
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Yingjie Liu
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Nana Wang
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Tiegang Li
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Yu Wang
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Mandi Li
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June 18, 2026
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Clinical Scorecard: Interactions Between Gut Barrier and Microbiota in Sepsis: Insights into Mechanisms and Therapeutic Approaches
At a Glance
| Category | Detail |
|---|
| Condition | Sepsis |
| Key Mechanisms | Interaction between intestinal epithelial barrier and gut microbiota; dysbiosis and altered permeability drive sepsis progression. |
| Target Population | Patients with sepsis and septic shock. |
| Care Setting | Clinical settings, including intensive care units. |
Key Highlights
- Sepsis is characterized by a dysregulated host response to infection.
- The gut microbiota and intestinal epithelial barrier play crucial roles in sepsis pathogenesis.
- Dysbiosis can impair the intestinal epithelial barrier, exacerbating systemic inflammation.
- Current therapies may adversely affect intestinal integrity.
- Emerging treatment strategies target gut function to improve sepsis outcomes.
Guideline-Based Recommendations
Diagnosis
- Use Sequential Organ Failure Assessment (SOFA) and Systemic Inflammatory Response Syndrome (SIRS) criteria for sepsis identification.
Management
- Focus on maintaining intestinal barrier integrity and addressing gut microbiota dysbiosis.
Monitoring & Follow-up
- Assess intestinal permeability and microbiota composition in sepsis patients.
Risks
- Increased susceptibility to sepsis and worsened prognosis due to gut barrier dysfunction.
Patient & Prescribing Data
Patients experiencing sepsis and septic shock.
Therapeutic strategies should consider the role of gut function and microbiota.
Clinical Best Practices
- Monitor gut health in sepsis patients.
- Implement strategies to restore gut microbiota balance.
- Evaluate the impact of supportive therapies on intestinal integrity.
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