Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs
-
By
-
Yiling Zhang
-
Xianghong He
-
Qian Zhao
-
Heping Li
-
Rui Qin
-
Weifang Zuo
-
Bo Han
-
May 7, 2026
-
Clinical Scorecard: Supplementation with grape seed proanthocyanidins reduces intestinal barrier impairment caused by diquat in weaned pigs
At a Glance
| Category | Detail |
|---|
| Condition | Intestinal barrier impairment due to oxidative stress from diquat in weaned pigs |
| Key Mechanisms | Grape seed proanthocyanidins (GSP) enhance antioxidant capacity and intestinal microbiota, reduce oxidative stress markers, and improve intestinal morphology. |
| Target Population | Weaned pigs (Duroc × Landrace × Yorkshire) |
| Care Setting | Animal research facility |
Key Highlights
- GSP supplementation reduced serum urea levels and increased superoxide dismutase activity.
- GSP improved ileal villi height and villus-to-crypt ratios in diquat-challenged pigs.
- GSP down-regulated apoptotic markers and up-regulated tight junction proteins.
- GSP increased beneficial gut microbiota populations in the cecum and colon.
Guideline-Based Recommendations
Diagnosis
- Assess intestinal barrier function and oxidative stress markers in weaned pigs.
Management
- Consider GSP supplementation in diets for weaned pigs to mitigate oxidative stress.
Monitoring & Follow-up
- Monitor serum urea levels and antioxidant enzyme activity as indicators of intestinal health.
Risks
- Potential for oxidative stress-related intestinal damage in weaned pigs without GSP supplementation.
Patient & Prescribing Data
Weaned pigs subjected to oxidative stress via diquat administration.
50 mg/kg GSP supplementation effectively mitigates intestinal damage and enhances gut health.
Clinical Best Practices
- Incorporate GSP into the diet of weaned pigs to improve intestinal health.
- Regularly evaluate gut microbiota composition and intestinal morphology in response to dietary interventions.
Related Resources & Content
