Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer - Scorecard - MDSpire

Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer

  • By

  • Qi Han

  • Zichao Li

  • Hongyi Xiao

  • Fanceng Ji

  • Chunhui Zheng

  • Qinglan Li

  • June 15, 2026

  • 0 min

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Clinical Scorecard: Impact of Intranasal Dexmedetomidine on Perioperative Anxiety and Postoperative Recovery in Breast Cancer Patients Undergoing Modified Radical Mastectomy

At a Glance

CategoryDetail
Condition
Key MechanismsIntranasal administration of dexmedetomidine for sedation and anxiety reduction (source needed).
Target Population
Care Setting

Key Highlights

  • Dexmedetomidine significantly reduced perioperative anxiety (PAS-7 score) (source needed).
  • Improved postoperative recovery quality (QoR-15 scores) at 24 and 48 hours (source needed).
  • No significant adverse effects on intraoperative hemodynamics (source needed).
  • Longer time to emergence in dexmedetomidine group compared to control (source needed).
  • Study conducted with 90 participants, randomized and double-blind design (source needed).

Guideline-Based Recommendations

Diagnosis

    Management

    • C
    • o
    • n
    • s
    • i
    • d
    • e
    • r
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    • n
    • t
    • r
    • a
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    • l
    • d
    • e
    • x
    • m
    • e
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    • t
    • o
    • m
    • i
    • d
    • i
    • n
    • e
    • f
    • o
    • r
    • a
    • n
    • x
    • i
    • e
    • t
    • y
    • r
    • e
    • d
    • u
    • c
    • t
    • i
    • o
    • n
    • i
    • n
    • b
    • r
    • e
    • a
    • s
    • t
    • c
    • a
    • n
    • c
    • e
    • r
    • s
    • u
    • r
    • g
    • e
    • r
    • y
    • (
    • s
    • o
    • u
    • r
    • c
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    • n
    • e
    • e
    • d
    • e
    • d
    • )
    • .

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Female breast cancer patients undergoing surgery

        Dexmedetomidine administered intranasally based on body weight

        Clinical Best Practices

          Related Resources & Content

          Original Source(s)

          Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer

          • by Qi Han, Zichao Li, Hongyi Xiao, Fanceng Ji, Chunhui Zheng, Qinglan Li

          • June 15, 2026

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