Development and validation of a prediction model for 1-year all-cause rehospitalisation after discharge in patients with heart failure with preserved ejection fraction based on the systemic immune-inflammation index - Scorecard - MDSpire
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Development and validation of a prediction model for 1-year all-cause rehospitalisation after discharge in patients with heart failure with preserved ejection fraction based on the systemic immune-inflammation index
Clinical Scorecard: Creation and assessment of a predictive model for 1-year all-cause readmission following discharge in heart failure patients with preserved ejection fraction utilizing the systemic immune-inflammation index
At a Glance
Category
Detail
Condition
Heart Failure with Preserved Ejection Fraction (HFpEF)
Key Mechanisms
Systemic immune-inflammation index (SII), NT-proBNP, renal function, lipoprotein(a), hypertension
Target Population
Patients with HFpEF aged ≥18 years
Care Setting
Single-center observational study at Fuyang People's Hospital
Key Highlights
Model developed to predict 1-year all-cause readmission in HFpEF patients
Strong discrimination with AUC of 0.8468 in training cohort and 0.8302 in validation cohort
Key predictors include LnSII, LnNT-proBNP, LnLp(a), GFR, and hypertension
Sensitivity and specificity at optimal threshold: 0.7101 and 0.8993 (training), 0.5333 and 0.8750 (validation)
Calibration deemed acceptable via Hosmer–Lemeshow test
Guideline-Based Recommendations
Diagnosis
Confirm diagnosis of HFpEF per 2022 AHA/ACC/HFSA guidelines
Management
Utilize predictive model for risk stratification in clinical settings
Monitoring & Follow-up
Follow-up on rehospitalization rates within 1 year post-discharge
Risks
Consider systemic inflammation and renal function as significant risk factors
Patient & Prescribing Data
Patients with HFpEF treated at Fuyang People's Hospital
Incorporate SII and other biomarkers in treatment planning
Clinical Best Practices
Employ the predictive model for personalized risk assessment
Monitor inflammatory markers and renal function in HFpEF patients
Ensure comprehensive follow-up to minimize readmission rates
