Development and Experimental Validation of an Osteoporosis Diagnosis Model Based on Disulfidoptosis-related Genes and Immune Infiltration Analysis - Scorecard - MDSpire

Development and Experimental Validation of an Osteoporosis Diagnosis Model Based on Disulfidoptosis-related Genes and Immune Infiltration Analysis

  • By

  • Yang, Ping

  • Chen, Minzhi

  • Zhang, Junxiang

  • Liu, Zhonghua

  • May 14, 2026

  • 0 min

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Clinical Scorecard: Creation and Experimental Confirmation of a Diagnostic Model for Osteoporosis Utilizing Disulfidoptosis-Associated Genes and Immune Infiltration Assessment

At a Glance

CategoryDetail
ConditionOsteoporosis
Key MechanismsDisulfidoptosis-related genes and immune infiltration patterns
Target PopulationIndividuals at risk for osteoporosis
Care SettingClinical and research settings

Key Highlights

  • Identification of 299 disulfidoptosis-related differentially expressed genes (DRDEGs)
  • Construction of a diagnostic model based on three hub genes: SOAT2, FOLR3, TUBA8
  • Moderate diagnostic accuracy in internal validation (AUC: 0.7-0.9) and high accuracy in external validation (AUC > 0.9)
  • Distinct immune infiltration patterns correlated with key genes
  • Experimental validation confirmed dysregulation of genes during osteoclast differentiation

Guideline-Based Recommendations

Diagnosis

  • Utilize the diagnostic model based on identified hub genes for osteoporosis diagnosis

Management

  • Consider immune infiltration patterns in the management of osteoporosis

Monitoring & Follow-up

  • Monitor expression levels of hub genes during treatment

Risks

  • Assess potential immune heterogeneity in osteoporosis patients

Patient & Prescribing Data

Patients with osteoporosis or at risk for osteoporosis

Potential for precision medicine approaches based on molecular signatures

Clinical Best Practices

  • Incorporate disulfidoptosis-related gene analysis in osteoporosis assessment
  • Utilize machine learning algorithms for diagnostic model development
  • Conduct immune infiltration assessments to inform treatment strategies

Related Resources & Content

    Original Source(s)

    Development and Experimental Validation of an Osteoporosis Diagnosis Model Based on Disulfidoptosis-related Genes and Immune Infiltration Analysis

    • by Yang, Ping , Chen, Minzhi , Zhang, Junxiang , Liu, Zhonghua

    • May 14, 2026

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