Extended Ex-Situ Heart Perfusion Maintains Cardiac Function After Orthotopic Transplantation in a Pig Model
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By
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Zhuldyz Nurmykhametova
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Rymbay Kaliyev
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Timur Lesbekov
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Linar Faizov
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Assel Medressova
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Aiym Turarova
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Yerik Zuparov
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Yuriy Pya
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April 15, 2026
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Clinical Scorecard: Extended Ex-Situ Heart Perfusion Maintains Cardiac Function After Orthotopic Transplantation in a Pig Model
At a Glance
| Category | Detail |
|---|
| Condition | Heart Transplantation |
| Key Mechanisms | Normothermic ex-situ heart perfusion (ESHP) using ECMO-based system |
| Target Population | Porcine model (domestic pigs, 90-95 kg, 6-8 months old) |
| Care Setting | Experimental animal research |
Key Highlights
- 24-hour preservation of porcine hearts using ECMO-based ESHP maintained function post-transplant.
- Cardiac output increased significantly post-transplantation, indicating preserved graft viability.
- No acute graft dysfunction observed during the monitoring period.
Guideline-Based Recommendations
Diagnosis
- Monitor hemodynamic parameters using Swan-Ganz catheter.
Management
- Utilize ECMO-based ESHP for extended heart preservation.
Monitoring & Follow-up
- Assess cardiac output, oxygen delivery, and lactate levels post-transplant.
Risks
- Potential for myocardial functional decline due to metabolic disturbances during prolonged ESHP.
Patient & Prescribing Data
Not applicable (animal study)
ECMO-based ESHP can potentially expand donor heart preservation time beyond traditional limits.
Clinical Best Practices
- Maintain coronary perfusion pressure between 60-70 mmHg during ESHP.
- Supplement metabolic and hormonal factors during preservation.
References
