Female sex is not associated with worse surgical outcomes in infective endocarditis: a prospective study disproving a common assumption - Scorecard - MDSpire
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Female sex is not associated with worse surgical outcomes in infective endocarditis: a prospective study disproving a common assumption
Clinical Scorecard: Gender does not correlate with poorer surgical results in infective endocarditis: findings from a prospective study challenging a prevalent belief
At a Glance
Category
Detail
Condition
Infective Endocarditis
Key Mechanisms
Sex-based disparities in surgical access and outcomes.
Target Population
Patients diagnosed with infective endocarditis requiring surgical intervention.
Care Setting
Tertiary referral center
Key Highlights
No significant sex-related differences in in-hospital mortality (12.8% overall).
Women had lower rates of surgical intervention despite similar indications.
Female sex did not emerge as an independent predictor of in-hospital mortality or mid-term outcomes.
Guideline-Based Recommendations
Diagnosis
Definite infective endocarditis diagnosis according to current ESC guidelines.
Management
Standardized antimicrobial and surgical treatment strategies according to the Endocarditis Team model.
Monitoring & Follow-up
Assess mid-term outcomes including all-cause mortality, repeat cardiac surgery, hospital readmission for heart failure, or relapse/reinfection of IE.
Risks
Consider potential disparities in surgical access based on sex.
Patient & Prescribing Data
264 patients diagnosed and treated for infective endocarditis.
Comorbidities and clinical presentation were comparable between sexes.
Clinical Best Practices
Individualized clinical judgment and multidisciplinary discussion to prevent treatment disparities.
by N. Pavone, E. M. d’Acierno, G. Mazzenga, F. Cammertoni, M. Calabrese, F. Giovannenze, N. Testa, G. Scoppettuolo, A. Pasquini, M. Grandinetti, E. Romagnoli, G. A. Chiariello, P. Bruno, M. Massetti
