Clinical Scorecard: Allergens from Blomia tropicalis Cause Alterations in Lung DNA Methylation of Neuroimmune Genes in a Mouse Model of Airway Inflammation
At a Glance
Category
Detail
Condition
Allergic asthma
Key Mechanisms
DNA methylation changes in lung tissue due to exposure to Blomia tropicalis allergens
Target Population
Mice (BALB/c strain)
Care Setting
Experimental laboratory model of acute allergic airway inflammation
Key Highlights
Distinct lung DNA methylation profiles observed in allergen-exposed mice compared to controls
Identification of 137, 179, and 313 differentially methylated regions (DMRs) for Blo t 2, Blo t 13, and B. tropicalis extract, respectively
Key genes affected include protocadherin alpha genes, cadherin 8, and interleukin 11 receptor alpha
Significant differences in mRNA levels of neuronal growth genes and proapoptotic gene Bcl2l11
Findings suggest epigenetic reprogramming in the lung due to allergen exposure
by Kevin Llinás-Caballero, Nathalie Acevedo, Simon Kebede Merid, Karen Donado, Hector Espinoza, Ernesto Mondol, Randy Reina, Ronald Regino, Inés Benedetti, Josefina Zakzuk, Leonardo Puerta, Erik Melén, Luis Caraballo
