Integrating clinical decision support systems, nursing vigilance, and physician prescribing patterns to reduce preventable adverse drug events: a structured evidence-based narrative review on human-AI interface in medication safety - Scorecard - MDSpire

Integrating clinical decision support systems, nursing vigilance, and physician prescribing patterns to reduce preventable adverse drug events: a structured evidence-based narrative review on human-AI interface in medication safety

  • By

  • Manar Fayez Alruwaili

  • Ugwu Okechukwu Paul-Chima

  • Ugwu Chinyere Nneoma

  • July 7, 2026

  • 0 min

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Clinical Scorecard: Enhancing Medication Safety: A Comprehensive Review of Clinical Decision Support Systems, Nursing Oversight, and Physician Prescribing Trends to Mitigate Preventable Adverse Drug Events in the Context of Human-AI Interaction

At a Glance

CategoryDetail
ConditionPreventable Adverse Drug Events (ADEs)
Key MechanismsClinical decision support systems (CDSS) and artificial intelligence (AI) integration
Target PopulationPatients in acute, community, and long-term care settings
Care SettingHealthcare systems utilizing digital health technologies

Key Highlights

  • Preventable ADEs account for significant hospital morbidity and mortality.
  • CDSS effectiveness in reducing ADEs is mixed due to alert fatigue and technology-induced errors.
  • AI and machine learning present both opportunities for safety enhancement and new risks.
  • Nursing vigilance plays a critical role in medication safety.
  • The Clinical Safety Intelligence Loop (CSIL) framework is proposed for integrating AI into medication safety.

Guideline-Based Recommendations

Diagnosis

  • Evaluate the effectiveness of CDSS in reducing preventable ADEs.

Management

  • Implement systems-level approaches integrating AI, clinician cognition, and organizational culture.

Monitoring & Follow-up

  • Assess the impact of alert fatigue and technology-induced errors on medication safety.

Risks

  • Address algorithmic bias and technology-induced medication errors.

Patient & Prescribing Data

Patients receiving medications in various healthcare settings.

Integration of AI and CDSS can enhance medication safety but requires careful governance.

Clinical Best Practices

  • Utilize adaptive decision support to improve clinician engagement.
  • Monitor and mitigate alert fatigue among healthcare providers.
  • Foster collaboration between nursing and prescribing teams to enhance vigilance.

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