Long-term psychological and functional outcomes after hepatitis C eradication with direct-acting antivirals: an 80-month follow-up study - Scorecard - MDSpire
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Eighty-Month Follow-Up on Psychological and Functional Outcomes Following Hepatitis C Treatment with Direct-Acting Antivirals

  • By

  • Salvatore Cipolla

  • Pierluigi Catapano

  • Maria Chiara Della Corte

  • Daniele De Francesco

  • Antonio Volpicelli

  • Iolanda Cafarella

  • Filomena Boccia

  • Lorenzo Bertolino

  • Emanuele Durante-Mangoni

  • Rosa Zampino

  • Mario Luciano

  • May 25, 2026

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Clinical Scorecard: Eighty-Month Follow-Up on Psychological and Functional Outcomes Following Hepatitis C Treatment with Direct-Acting Antivirals

At a Glance

CategoryDetail
ConditionHepatitis C Virus (HCV) Infection
Key MechanismsDirect-acting antivirals (DAAs) improve virological cure rates and reduce adverse events.
Target PopulationPatients with chronic HCV infection, with and without psychiatric history.
Care SettingIntegrated medical–psychological follow-up in HCV management.

Key Highlights

  • 38.7% of original cohort reassessed at 80 months post-DAA initiation.
  • Significant improvement in depressive and anxiety symptoms in patients with psychiatric history.
  • Stable psychological profiles in patients without psychiatric history.
  • Decline in physical quality of life observed in both groups.
  • Avoidant coping and psychiatric history negatively predict long-term anxiety change.

Guideline-Based Recommendations

Diagnosis

  • Evaluate psychopathological symptoms using standardized scales (HAM-D, HAM-A, SCL-90-R).
  • Assess coping strategies and quality of life (SF-36).

Management

  • Integrate psychiatric evaluation and follow-up in HCV treatment plans.

Monitoring & Follow-up

  • Regularly assess psychological well-being and quality of life post-treatment.

Risks

  • Consider the impact of psychiatric history on treatment outcomes and coping strategies.

Patient & Prescribing Data

Patients with chronic HCV infection, both with and without prior psychiatric conditions.

DAAs are associated with sustained long-term psychiatric safety and improvements in mood.

Clinical Best Practices

  • Implement integrated care approaches for HCV patients to address both medical and psychological needs.
  • Monitor for changes in quality of life and psychiatric symptoms over time.

Related Resources & Content

    Original Source(s)

    Long-term psychological and functional outcomes after hepatitis C eradication with direct-acting antivirals: an 80-month follow-up study

    • by Salvatore Cipolla, Pierluigi Catapano, Maria Chiara Della Corte, Daniele De Francesco, Antonio Volpicelli, Iolanda Cafarella, Filomena Boccia, Lorenzo Bertolino, Emanuele Durante-Mangoni, Rosa Zampino, Mario Luciano

    • May 25, 2026

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