Clinical Scorecard: Evaluation of Consistency in Quantitative Indocyanine Green Fluorescence Angiography Across Different Software Platforms in Reconstructive Surgery

At a Glance

Key Highlights

• Excellent agreement for time-to-peak (TTP) with ICC = 0.979.
• Normalized mean slope inflow showed good agreement (ICC = 0.944).
• Significant systematic differences observed for six out of seven parameters.
• AMS platform reported higher TTP values compared to EPA (p < 0.001).
• Bland–Altman analysis indicated wide limits of agreement for TTP.

Guideline-Based Recommendations

Diagnosis

• Use quantitative indocyanine green fluorescence angiography for objective perfusion assessment.

Management

• Consider TTP and normalized mean slope inflow as reliable metrics for perfusion thresholds.

Monitoring & Follow-up

• Evaluate consistency of Q-ICG-FA parameters across different software platforms.

Risks

• Potential for interobserver variability in qualitative assessments of perfusion.

Patient & Prescribing Data

Patients undergoing various types of reconstructive surgery.

ICG administered intravenously at a dose of 0.1 mg/kg for perfusion assessment.

Clinical Best Practices

• Standardize imaging protocols for Q-ICG-FA to enhance reproducibility.
• Utilize both AMS and EPA software for comparative analysis of perfusion parameters.

Related Resources & Content

• ClinicalTrials.gov ID: NCT06129669