The landscape of cocaine cytotoxicity and the role of sigma-1 receptor modulation and adulterant synergism - Scorecard - MDSpire

The landscape of cocaine cytotoxicity and the role of sigma-1 receptor modulation and adulterant synergism

  • By

  • Aline Steinmetz

  • Carlo Frederico Moro

  • Luana Freese

  • Murilo Sander de Abreu

  • Rodrigo Ligabue Braum

  • Helena Maria Tannhauser Barros

  • Dinara Jaqueline Moura

  • May 13, 2026

  • 0 min

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Clinical Scorecard: Exploring Cocaine-Induced Cytotoxicity: The Impact of Sigma-1 Receptor Modulation and Synergistic Effects of Adulterants

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationCocaine users, particularly those with adulterant exposure, including demographics such as age and gender.
Care Setting

Key Highlights

  • Clarify the role of sigma-1 receptors in mediating cocaine's cytotoxicity.

Guideline-Based Recommendations

Diagnosis

    Management

    • Provide supportive care for acute cocaine toxicity.
    • Consider interventions for managing oxidative stress, such as antioxidants.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Individuals using cocaine, especially with known adulterants.

        Focus on managing oxidative stress and supporting organ function.

        Clinical Best Practices

        • Implement harm reduction strategies for cocaine users.
        • Educate patients on the risks of adulterants in cocaine.
        • Encourage participation in addiction treatment programs.
        • Include evidence-based practices for monitoring and follow-up care.

        Related Resources & Content

        Original Source(s)

        The landscape of cocaine cytotoxicity and the role of sigma-1 receptor modulation and adulterant synergism

        • by Aline Steinmetz, Carlo Frederico Moro, Luana Freese, Murilo Sander de Abreu, Rodrigo Ligabue Braum, Helena Maria Tannhauser Barros, Dinara Jaqueline Moura

        • May 13, 2026

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