Sex-dependent transcriptional and epigenetic regulation of neutrophil inflammatory programs in COPD
By
Barbara Mariotti
Sara Gasperini
Chiara Bracaglia
Carlo Frigenti
Giulia Sartori
Claudia di Chiara
Francesca Sangiovanni
Ernesto Crisafulli
Flavia Bazzoni
May 28, 2026
Clinical Scorecard: Transcriptional and Epigenetic Modulation of Neutrophil Inflammatory Pathways in COPD: Influence of Biological Sex
At a Glance
Category Detail
Condition Key Mechanisms Sex-dependent regulatory programs in innate immune cells, including specific roles of transcriptional and epigenetic reprogramming of neutrophils. Target Population Care Setting
Key Highlights
Sex represents a major source of transcriptional variation in neutrophils. Male COPD neutrophils show robust enrichment of inflammatory pathways. Female neutrophils exhibit transcriptional programs related to autophagy. COPD elicits a shared neutrophil transcriptional framework amplified by sex-specific feedback. Increased understanding of sex differences is crucial for precision therapies in COPD. Findings suggest potential new therapeutic targets based on sex differences. Guideline-Based Recommendations
Diagnosis
Management
Tailor treatment approaches based on sex-specific immune responses, such as corticosteroid sensitivity. Monitoring & Follow-up
Risks
Patient & Prescribing Data
Sex-specific differences in inflammatory mediator levels may influence treatment efficacy, necessitating personalized treatment plans.
Clinical Best Practices
Incorporate sex differences in clinical assessments and treatment plans for COPD. Utilize transcriptomic and epigenomic profiling to inform therapeutic strategies, such as identifying biomarkers for treatment response. Related Resources & Content
