Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease - Scorecard - MDSpire

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

  • By

  • Mike Seed

  • Dawn Ilardi

  • Valerie Rofeberg

  • Cynthia Ortinau

  • Caren Goldberg

  • Garrett Reichle

  • Lauren Bush

  • Justin Elhoff

  • Amy Jo Lisanti

  • Jennifer Butcher

  • Caitlin Rollins

  • Andrew Van Bergen

  • Shabnam Peyvandi

  • Emily Bucholz

  • Stephanie Cox

  • Lyla Hampton

  • Jacqueline Sanz

  • Sonia Monteiro

  • Shruti Tewar

  • Kiona Allen

  • Caroline Lee

  • Kristi Glotzbach

  • Nneka Alexander

  • Laurel Bear

  • Corinne Anton

  • Renee Sananes

  • Linh Ly

  • Gina Boucher

  • Kelly Wolfe

  • Lindsay Edwards

  • Elizabeth Willen

  • Alexander Tan

  • Christina Ortega

  • Erica Sood

  • Anjali Sadhwani

  • Kari Crawford Plant

  • Lauren Quigley

  • Jessica Pliego

  • Elizabeth Valles

  • Abbey Hines

  • David Wypij

  • Thomas Miller

  • June 1, 2026

  • 0 min

Share

Clinical Scorecard: Initial Neurodevelopmental Results in Pediatric Patients with Congenital Heart Disease

At a Glance

CategoryDetail
ConditionCongenital Heart Disease (CHD)
Key MechanismsMultifactorial causes including genetic variation, maternal health, fetal cardiovascular physiology, and postnatal medical and environmental risks.
Target PopulationInfants and toddlers undergoing surgical repair for CHD.
Care SettingMultinational, multicenter clinical data registry.

Key Highlights

  • Neurodevelopmental delays affect up to 50% of children requiring surgical intervention for CHD.
  • Early delays may progress to cognitive and social-emotional concerns.
  • Clinical risk factors include genetic diagnoses, prolonged hospitalization, and preterm birth.
  • Social drivers such as parental education and socioeconomic status impact neurodevelopmental outcomes.
  • Outcomes may differ by cardiac diagnosis, with evolving associations due to changes in perioperative management.

Guideline-Based Recommendations

Diagnosis

  • Use standardized neurodevelopmental measures for assessment.

Management

  • Monitor neurodevelopmental outcomes in infants and toddlers post-surgery.

Monitoring & Follow-up

  • Collect sociodemographic and medical data through clinical registries.

Risks

  • Identify and address clinical and social risk factors associated with neurodevelopmental delays.

Patient & Prescribing Data

Infants and toddlers aged 11 to 30 months who underwent cardiopulmonary bypass surgery.

Neurodevelopmental assessments should be integrated with perioperative data.

Clinical Best Practices

  • Utilize the Bayley Scales of Infant and Toddler Development for neurodevelopmental assessment.
  • Incorporate genetic testing where clinically indicated to evaluate neurodevelopmental risks.

Related Resources & Content

Original Source(s)

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

  • by Mike Seed, Dawn Ilardi, Valerie Rofeberg, Cynthia Ortinau, Caren Goldberg, Garrett Reichle, Lauren Bush, Justin Elhoff, Amy Jo Lisanti, Jennifer Butcher, Caitlin Rollins, Andrew Van Bergen, Shabnam Peyvandi, Emily Bucholz, Stephanie Cox, Lyla Hampton, Jacqueline Sanz, Sonia Monteiro, Shruti Tewar, Kiona Allen, Caroline Lee, Kristi Glotzbach, Nneka Alexander, Laurel Bear, Corinne Anton, Renee Sananes, Linh Ly, Gina Boucher, Kelly Wolfe, Lindsay Edwards, Elizabeth Willen, Alexander Tan, Christina Ortega, Erica Sood, Anjali Sadhwani, Kari Crawford Plant, Lauren Quigley, Jessica Pliego, Elizabeth Valles, Abbey Hines, David Wypij, Thomas Miller

  • June 1, 2026

Related Content

Case Report: triple therapy with pembrolizumab, ipilimumab, and lenvatinib in mitotane- and radiation-refractory, cortisol-secreting stage IV adrenocortical carcinoma: a genomically guided approach

3 Medical Routines That Older People May Not Need

“The treatment may be more burdensome than the condition itself."

Side Effects: They Googled It

Patients are mining Reddit and TikTok for symptom intel while you're not — and a small study calls it epistemic injustice. Different knowledge, mutually unrecognized. Maybe ask where they've been reading before you wave it off as anecdote.