Multidisciplinary management promoting wound healing in a patient with Proteus syndrome: a case report
By
Yue Tan
Xu Zhang
Hai-Bin Wang
Li Wang
Wen-Shuang Qiu
June 15, 2026
Clinical Scorecard: Comprehensive Care Approach Enhancing Wound Healing in a Patient with Proteus Syndrome: A Case Study
At a Glance
Category Detail
Condition Proteus syndrome Key Mechanisms AKT1 gene mutations leading to asymmetric overgrowth and increased susceptibility to infections. Target Population Children and adolescents with Proteus syndrome. Care Setting Clinical setting with a focus on coordinated healthcare management.
Key Highlights
Proteus syndrome is characterized by asymmetric overgrowth and poor survival rates. A clinical pharmacist implemented individualized anti-infective interventions. The patient developed a severe soft tissue infection secondary to lower limb deformity. Optimized treatment led to significant improvement in wound healing. Current treatment focuses on symptom management without altering disease progression. Guideline-Based Recommendations
Diagnosis
Diagnosis based on clinical presentation and genetic testing for AKT1 mutations. Management
Individualized anti-infective treatment based on etiology, liver function, and body weight. Monitoring & Follow-up
Regular assessment of inflammatory indicators and liver function. Risks
Increased susceptibility to infections due to compromised skin barrier. Patient & Prescribing Data
14-year-old male with Proteus syndrome.
Optimized antibiotic regimen based on drug sensitivity and patient's liver function.
Clinical Best Practices
Implement a coordinated healthcare approach for managing Proteus syndrome complications. Utilize clinical pharmacists for individualized medication management. Related Resources & Content
