Case Report: Extranodal marginal zone B-cell lymphoma in the lateral ventricle: literature review
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By
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Yimeng Xue
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Zhuo Li
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Yun Cui
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Guilin Li
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Qing Chang
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Congwei Jia
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Jiang Du
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May 11, 2026
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Clinical Scorecard: Case Study: Primary Extranodal Marginal Zone B-cell Lymphoma in the Right Lateral Ventricle with a Review of Existing Literature
At a Glance
| Category | Detail |
|---|
| Condition | Primary CNS MALT lymphoma |
| Key Mechanisms | Low-grade B-cell lymphoma arising from marginal zone B cells, often mistaken for other lesions. |
| Target Population | Adults, specifically reported in a 62-year-old male. |
| Care Setting | Hospital setting with surgical and postoperative management. |
Key Highlights
- Exceedingly rare occurrence of MALT lymphoma in the ventricular system.
- Initial misdiagnosis as meningioma or metastasis is common.
- Postoperative treatment included ifosfamide and a BTK inhibitor.
- Complete resection led to no evidence of recurrence at follow-up.
Guideline-Based Recommendations
Diagnosis
- Consider MALT lymphoma in differential diagnosis of intraventricular lesions.
- Utilize MRI for imaging characterization.
Management
- Gross total resection is recommended.
- Adjuvant therapy may include chemotherapy and radiotherapy.
Monitoring & Follow-up
- Regular follow-up MRI to assess for recurrence.
Risks
- Potential for misdiagnosis on imaging.
- Chronic inflammation may be a contributing factor.
Patient & Prescribing Data
62-year-old male with primary CNS MALT lymphoma.
Postoperative treatment with ifosfamide and a BTK inhibitor followed by radiotherapy.
Clinical Best Practices
- Thorough preoperative evaluation including imaging and CSF analysis.
- Consideration of chronic infections as potential triggers.
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