The association between C-reactive protein-triglyceride glucose index and all-cause mortality in patients with cardiovascular-kidney-metabolic syndrome: a single-center retrospective cohort study - Scorecard - MDSpire

The association between C-reactive protein-triglyceride glucose index and all-cause mortality in patients with cardiovascular-kidney-metabolic syndrome: a single-center retrospective cohort study

  • By

  • Jiacai Lin

  • Shaobin Qiu

  • Shuling Su

  • Weixin Ni

  • Yongluan Lin

  • Xiaobin Ni

  • July 8, 2026

  • 0 min

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Clinical Scorecard: The Relationship Between C-Reactive Protein-Triglyceride Glucose Index and Overall Mortality in Individuals with Cardiovascular-Kidney-Metabolic Syndrome: A Retrospective Cohort Analysis from a Single Center

At a Glance

CategoryDetail
ConditionCardiovascular-Kidney-Metabolic Syndrome
Key MechanismsIntegration of inflammation and insulin resistance
Target PopulationPatients with CKM syndrome
Care SettingRetrospective cohort study

Key Highlights

  • CTI is an independent predictor of all-cause mortality in CKM patients.
  • Higher CTI quartiles correlate with increased mortality risk.
  • CTI shows superior predictive performance over TyG index.
  • A linear dose-response relationship exists between CTI and mortality.
  • Study included 8,632 CKM patients with 860 deaths (10.0%).

Guideline-Based Recommendations

Diagnosis

  • CKM syndrome staged according to AHA criteria.

Management

  • Utilization of CTI for risk stratification in CKM patients.

Monitoring & Follow-up

  • Regular assessment of CTI levels to evaluate mortality risk.

Risks

  • Increased mortality risk associated with higher CTI levels.

Patient & Prescribing Data

Adults (age ≥ 18 years) with CKM syndrome.

CTI may guide tailored interventions to improve outcomes.

Clinical Best Practices

  • Incorporate CTI in routine assessments for CKM patients.
  • Monitor inflammatory and metabolic markers in CKM management.

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