Trends in urolithiasis mortality in the United States, 1999–2024: a Joinpoint regression analysis of age, sex, race, and regional disparities - Scorecard - MDSpire
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Analysis of Mortality Trends Associated with Urolithiasis in the United States from 1999 to 2024: A Joinpoint Regression Study Examining Age, Gender, Ethnicity, and Geographic Variations

  • By

  • Li-Li Xu

  • Chu-xuan Lin

  • Xin-yi Lin

  • Qin-ying Zhou

  • Nai-fen Xu

  • Ding-qin Zheng

  • Ran Xu

  • August 21, 2026

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Clinical Scorecard: Analysis of Mortality Trends Associated with Urolithiasis in the United States from 1999 to 2024: A Joinpoint Regression Study Examining Age, Gender, Ethnicity, and Geographic Variations

At a Glance

CategoryDetail
ConditionUrolithiasis
Key MechanismsMortality trends associated with demographic and geographic disparities.
Target PopulationAdults aged ≥45 years.
Care SettingPublic health analysis using CDC WONDER database.

Key Highlights

  • Urolithiasis mortality rose from 0.22 to 0.72 per 100,000 population from 1999 to 2024.
  • Significant increase in mortality observed post-2014, with an annual percent change of 8.54%.
  • Females had a higher age-adjusted mortality rate than males by 2024.
  • Non-Hispanic white individuals experienced the highest mortality rate at 0.86 per 100,000.
  • The highest mortality rate was among individuals aged 85 years and older, reaching 5.72 per 100,000.

Guideline-Based Recommendations

Diagnosis

  • Utilize ICD-10 codes N20–N23 for identifying urolithiasis-related deaths.

Management

  • Targeted interventions needed for high-risk populations including older adults and non-Hispanic white individuals.

Monitoring & Follow-up

  • Regular assessment of mortality trends across demographic and geographic groups.

Risks

  • Increased mortality associated with advancing age and demographic disparities.

Patient & Prescribing Data

Adults aged ≥45 years with urolithiasis.

Consider demographic factors and geographic location when planning treatment.

Clinical Best Practices

  • Implement public health strategies to address rising mortality trends.
  • Focus on high-risk settings, particularly in the Midwest and rural areas.

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