Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis
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By
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Jinfeng Li
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Terukazu Sanui
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Miyu Shida
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Karen Yotsumoto
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Mwannes Ahmad
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Ziyu Wang
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Meng Xiao
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Chikako Hayashi
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Takanori Shinjo
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Takaharu Taketomi
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Takao Fukuda
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Fusanori Nishimura
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May 26, 2026
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Clinical Scorecard: Periodontitis Induced by Ligature in Mice May Accelerate CD4+ T-Cell Aging and Worsen Rheumatoid Arthritis
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | Middle-aged individuals (both genders) with chronic periodontitis |
| Care Setting | |
Key Highlights
- Chronic periodontitis accelerates CD4+ T-cell senescence, particularly through specific SASP cytokines.
- Increased levels of SASP cytokines observed in LIP group, including IL-6 and osteopontin.
- Adoptive transfer of senescent CD4+ T cells exacerbates rheumatoid arthritis.
Guideline-Based Recommendations
Diagnosis
Management
- Consider the impact of periodontal health on systemic diseases like rheumatoid arthritis.
- Implement specific periodontal treatments such as scaling and root planing.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Addressing periodontal health may mitigate systemic inflammatory responses; consider anti-inflammatory medications.
Clinical Best Practices
- Integrate periodontal assessments in the management of autoimmune diseases, including routine screenings.
- Educate patients on the systemic implications of periodontal disease and provide resources for management.
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