The effect of therapeutic horticulture on non-suicidal self-injury in adolescents with major depressive disorder: protocol for a randomized controlled trial - Scorecard - MDSpire

The effect of therapeutic horticulture on non-suicidal self-injury in adolescents with major depressive disorder: protocol for a randomized controlled trial

  • By

  • Huang, Lei

  • Hong, Tian-Dan

  • Liang, Shi-cong

  • Huang, Zhao-Jun

  • Liang, Yong-Xin

  • Shen, Ling-Fang

  • Xia, Zhi-Chun

  • May 18, 2026

  • 0 min

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Clinical Scorecard: Investigating the Impact of Therapeutic Horticulture on Non-Suicidal Self-Injury in Adolescents Diagnosed with Major Depressive Disorder: A Randomized Controlled Trial Protocol

At a Glance

CategoryDetail
ConditionMajor Depressive Disorder and Non-Suicidal Self-Injury
Key MechanismsTherapeutic Horticulture engages patients in planting, nurturing, and harvesting plants as a therapeutic medium.
Target PopulationAdolescents aged 12-18 years diagnosed with MDD and NSSI
Care SettingSingle-center trial at the Brain Hospital Affiliated with Guangzhou Medical University, Guangdong, China

Key Highlights

  • Rising incidence of MDD and NSSI among adolescents is a public health challenge.
  • Existing interventions face limitations such as low patient willingness and poor adherence.
  • Therapeutic Horticulture may provide a novel treatment option for adolescents with comorbid MDD and NSSI.
  • The trial will assess the efficacy of TH on NSSI and psychosocial functioning.
  • Outcomes will be evaluated at baseline and immediately post-intervention.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis of MDD and NSSI per DSM-5 criteria.

Management

  • Control group will receive treatment as usual; intervention group will receive TH in addition to treatment as usual for two weeks.

Monitoring & Follow-up

  • Outcomes assessed at baseline (T0) and immediately post-intervention (T1).

Risks

  • Exclusion criteria include comorbid other mental disorders, history of serious physical illness, recent systematic horticultural therapy, allergies, or suicidal risk behaviors.

Patient & Prescribing Data

Adolescents aged 12-18 years with MDD and NSSI.

TH may enhance treatment adherence and engagement in therapeutic activities.

Clinical Best Practices

  • Informed consent must be obtained from participants.
  • Ensure adequate comprehension, communication, and writing abilities in participants.

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