Case Study: Non-secretory Multiple Myeloma with Eosinophilia - Diagnostic Hurdles and a Comprehensive Literature Review
By
Jirui Zhong
Xikun Liu
Jiduo Liu
Shanshan Xiao
Xuekui Gu
Zenghui Liu
April 22, 2026
Clinical Scorecard: Case Study: Non-secretory Multiple Myeloma with Eosinophilia - Diagnostic Hurdles and a Comprehensive Literature Review
At a Glance
Category Detail
Condition Key Mechanisms Target Population Adults, particularly those presenting with unexplained bone pain and eosinophilia, aged 40-70. Care Setting
Key Highlights
NSMM accounts for approximately 3% of multiple myeloma cases. Marked eosinophilia can obscure the diagnosis of NSMM. Diagnosis requires comprehensive evaluation including bone marrow examination and cytogenetic studies. Imaging typically reveals multifocal osteolytic lesions. Negative monoclonal protein studies complicate diagnosis. Integration of clinical findings is crucial for accurate diagnosis. Guideline-Based Recommendations
Diagnosis
Management
Consider treatment options for multiple myeloma once diagnosed, including proteasome inhibitors and immunomodulatory drugs. Monitor for complications related to eosinophilia. Monitoring & Follow-up
Risks
Patient & Prescribing Data
Treatment should be tailored based on the specific characteristics of NSMM and patient response, considering options like bortezomib or lenalidomide.
Clinical Best Practices
Integrate clinical, laboratory, and imaging findings for accurate diagnosis. Be vigilant for atypical presentations of multiple myeloma. Adopt a multidisciplinary approach for comprehensive management. References
