Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study
By
Jing Wang
Xin Wang
Liming Wang
Xiao Zhang
Pengfei Zang
Wenlong Han
Lu Chen
Qingkai Wang
Yi Li
Liyi Cai
June 4, 2026
Clinical Scorecard: Relationship between urinary hCG patterns and miscarriage risk in women receiving embryo transfer: a prospective cohort analysis
At a Glance
Category Detail
Condition Early miscarriage after embryo transfer Key Mechanisms Dynamic trajectories of urinary human chorionic gonadotropin (hCG) Target Population Women undergoing frozen embryo transfer aged 20-40 years Care Setting Hebei Maternity Hospital
Key Highlights
Three distinct hCG trajectories identified: Low-Slow, Low-Steady, High-Steady Low-Slow trajectory associated with a significantly increased risk of miscarriage (aOR = 38.11) Low-Steady trajectory also linked to increased miscarriage risk (aOR = 1.60) Model 3 predicted miscarriage with an AUC of 0.857 Urinary hCG monitoring offers a non-invasive method for early pregnancy outcome prediction Guideline-Based Recommendations
Diagnosis
Monitor urinary hCG levels daily starting from day 7 post-embryo transfer Management
Identify abnormal hCG dynamics for risk stratification and personalized clinical management Monitoring & Follow-up
Utilize quantitative urinary hCG measurements to capture dynamic changes Risks
Increased risk of miscarriage associated with Low-Slow and Low-Steady hCG trajectories Patient & Prescribing Data
207 women undergoing frozen embryo transfer
Inclusion criteria focused on first-time frozen embryo transfer with specific health parameters
Clinical Best Practices
Implement daily urinary hCG monitoring for early pregnancy assessment Utilize trajectory modeling for predicting miscarriage risk Related Resources & Content
