Case Report: A rare triad of neoplasms: navigating synchronous accessory breast cancer, papillary thyroid carcinoma, and inflammatory nasal papilloma - Scorecard - MDSpire

Case Report: A rare triad of neoplasms: navigating synchronous accessory breast cancer, papillary thyroid carcinoma, and inflammatory nasal papilloma

  • By

  • Xiangning Zeng

  • Huang Huang

  • Yuzhong Hong

  • Qin Meng

  • Kaihua Ye

  • Lian Zhou

  • Huajun Li

  • Ying Chen

  • Jiawei Huang

  • Chuxia Feng

  • June 1, 2026

  • 0 min

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Clinical Scorecard: Case Study: Managing a Unique Combination of Synchronous Neoplasms: Accessory Breast Cancer, Papillary Thyroid Carcinoma, and Inflammatory Nasal Papilloma

At a Glance

CategoryDetail
ConditionSynchronous neoplasms including accessory breast carcinoma, papillary thyroid carcinoma, and nasal papilloma
Key MechanismsAccessory breast carcinoma arises from ectopic breast tissue; papillary thyroid carcinoma is a common thyroid malignancy; nasal papilloma is a benign epithelial tumor.
Target PopulationWomen with isolated axillary masses and normal breast imaging.
Care SettingMultidisciplinary team approach in a surgical department.

Key Highlights

  • Accessory breast carcinoma is often overlooked in differential diagnosis of axillary masses.
  • The patient had three synchronous primary tumors: accessory breast carcinoma, papillary thyroid carcinoma, and nasal papilloma.
  • A structured, sequenced management approach was employed, prioritizing the most aggressive malignancy.
  • Final pathology confirmed distinct tumors with no evidence of metastatic disease.
  • Adjuvant treatment included locoregional radiotherapy and endocrine therapy.

Guideline-Based Recommendations

Diagnosis

  • Consider accessory breast carcinoma in differential diagnosis of isolated axillary masses.
  • Use imaging and histopathological criteria to distinguish accessory breast carcinoma from metastatic disease.

Management

  • Employ a multidisciplinary team approach for managing multiple primary tumors.
  • Prioritize treatment based on the aggressiveness of the malignancy.

Monitoring & Follow-up

  • Regular follow-up imaging and clinical assessments post-treatment.

Risks

  • Risk of misdiagnosis leading to inappropriate management of accessory breast carcinoma.

Patient & Prescribing Data

60-year-old female with multiple primary tumors.

Neoadjuvant chemotherapy followed by sequential surgeries and adjuvant therapies.

Clinical Best Practices

  • Utilize a structured approach for diagnosing and managing synchronous neoplasms.
  • Involve a multidisciplinary team for complex cases.

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