Patients’ knowledge influences practice via attitudes toward hyperuricaemia: a mediation analysis
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By
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Hong Shi
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Yanrong Zhu
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Qianyu Guo
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Jing Li
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Tingting Lv
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Yanjun Wu
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Jun Li
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Jiajun Liu
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December 3, 2025
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Clinical Scorecard: The Impact of Patient Awareness on Clinical Practices Related to Hyperuricaemia: Insights from Mediation Analysis
At a Glance
| Category | Detail |
|---|
| Condition | Hyperuricaemia and its progression to gout |
| Key Mechanisms | Elevated serum urate levels influenced by lifestyle factors leading to gout manifestations |
| Target Population | Patients diagnosed with hyperuricaemia, including outpatients in Shanxi Province and Inner Mongolia, China |
| Care Setting | Outpatient clinical settings with integration of patient education and self-management |
Key Highlights
- Hyperuricaemia prevalence in China ranges from 5% to 25%, linked to lifestyle and obesity trends.
- Management includes lifestyle modification, pharmacologic urate-lowering therapy, and regular serum uric acid monitoring.
- Knowledge, attitude, and practice (KAP) model is critical for understanding patient behavior and improving hyperuricaemia outcomes.
Guideline-Based Recommendations
Diagnosis
- Identify hyperuricaemia through serum uric acid level measurement in outpatient settings.
Management
- Implement lifestyle modifications including diet control, weight management, reduced alcohol intake, and regular exercise.
- Prescribe pharmacologic urate-lowering therapy when clinically indicated.
- Incorporate patient education to enhance self-management capacity.
Monitoring & Follow-up
- Regularly monitor serum uric acid levels to assess treatment efficacy and disease progression.
Risks
- Elevated serum urate levels increase risk of gout development and progression to chronic tophaceous gout.
Patient & Prescribing Data
Outpatients diagnosed with hyperuricaemia in Shanxi Province and Inner Mongolia
Patient knowledge and attitudes significantly influence adherence to lifestyle and pharmacologic interventions, impacting clinical outcomes.
Clinical Best Practices
- Use validated questionnaires to assess patient knowledge, attitude, and practice regarding hyperuricaemia.
- Apply the KAP model to tailor educational interventions and support patient self-management.
- Ensure data quality in patient surveys by excluding invalid responses and using reliable online platforms.
- Engage multidisciplinary experts in rheumatology and nursing to guide clinical education and research.
References
