Association of TyG index with sepsis incidence and mortality: a prospective study with diabetes stratification
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By
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Shuying You
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Zhenhua Xing
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Jiaqing Hu
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May 28, 2026
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Clinical Scorecard: Relationship Between TyG Index and Sepsis Risk and Mortality: A Prospective Study Stratified by Diabetes Status
At a Glance
| Category | Detail |
|---|
| Condition | Sepsis |
| Key Mechanisms | Association of TyG index with insulin resistance and sepsis outcomes. |
| Target Population | Individuals with and without diabetes. |
| Care Setting | Prospective cohort study in a population-based setting. |
Key Highlights
- Study analyzed 428,207 participants from the UK Biobank.
- 12,410 sepsis events and 6,291 sepsis-related deaths documented over a median follow-up of 13.04 years.
- TyG index associated with an 18% higher risk of sepsis in diabetic individuals.
- No significant association found between TyG index and sepsis outcomes in non-diabetic participants.
- TyG index improved predictive performance of risk models for sepsis in diabetes.
Guideline-Based Recommendations
Diagnosis
- Assess TyG index as a potential biomarker for sepsis risk in diabetic patients.
Management
- Consider monitoring TyG index in diabetic patients for sepsis risk stratification.
Monitoring & Follow-up
- Regularly evaluate TyG index levels in individuals with diabetes.
Risks
- Increased sepsis risk associated with higher TyG index in diabetic individuals.
Patient & Prescribing Data
Diabetic and non-diabetic individuals.
Elevated TyG levels linked to increased sepsis risk in diabetic patients.
Clinical Best Practices
- Utilize TyG index for risk assessment in diabetic patients at risk for sepsis.
- Incorporate TyG index into clinical decision-making for sepsis prevention.
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