Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort - Scorecard - MDSpire

Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort

  • By

  • Qiong Wu

  • Jian Peng

  • Xiangzhi Xiao

  • Huashan Zhou

  • Yan Ouyang

  • Sufen Chen

  • Jue Hu

  • Yanhua Zhou

  • Tieqiao Feng

  • Wengao Zeng

  • June 11, 2026

  • 0 min

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Clinical Scorecard: Liver Injury Induced by Medications as a Significant Independent Predictor of In-Hospital Mortality in Patients with Tuberculous Meningitis: Evidence of Potential Age-Related Modifications in a Large Lifespan Cohort

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationNon-HIV patients with tuberculous meningitis (age range: pediatric and adult)
Care Setting

Key Highlights

  • Age-related modifications in DILI risk were observed.

Guideline-Based Recommendations

Diagnosis

  • DILI diagnosed using specific biochemical thresholds (e.g., ALT, AST levels) and clinical evolution

Management

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        DILI is a common complication during anti-tuberculosis treatment, necessitating careful monitoring.

        Clinical Best Practices

        • Prompt etiologic adjudication for suspected DILI
        • Utilization of structured workflows for DILI assessment
        • Educate patients on the risks and signs of DILI

        Related Resources & Content

        Original Source(s)

        Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort

        • by Qiong Wu, Jian Peng, Xiangzhi Xiao, Huashan Zhou, Yan Ouyang, Sufen Chen, Jue Hu, Yanhua Zhou, Tieqiao Feng, Wengao Zeng

        • June 11, 2026

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