Risk of macrovascular events among patients with ICD-defined neuromyelitis optica in Taiwan
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By
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Chih-Jaan Tai
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Kuang-Hua Huang
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Tsuei-Hung Wang
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Tung-Han Tsai
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Shuo-Yan Gau
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Vincent Ping-Sheng Lai
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Zheng-Ren Lin
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Chien-Ying Lee
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July 1, 2026
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Clinical Scorecard: Incidence of Macrovascular Events in Patients with ICD-Diagnosed Neuromyelitis Optica in Taiwan
At a Glance
| Category | Detail |
|---|
| Condition | Neuromyelitis Optica (NMO) |
| Key Mechanisms | Immune-mediated demyelination and axon damage affecting optic nerves and spinal cord. |
| Target Population | Patients with ICD-defined Neuromyelitis Optica in Taiwan. |
| Care Setting | Population-based cohort study using National Health Insurance Research Database. |
Key Highlights
- Patients with NMO have a higher risk of cardiovascular disease (CVD) and cerebrovascular disease (CBD).
- Adjusted hazard ratios indicate a 1.40 times higher risk for CVD and 3.37 times higher risk for CBD in NMO patients.
- Significant associations found between NMO and ischemic stroke, hemorrhagic stroke, and transient ischemic attack.
Guideline-Based Recommendations
Diagnosis
- NMO diagnosed using ICD-9-CM 341.0 and ICD-10-CM G36.0 criteria.
Management
- Monitor for macrovascular events in patients with NMO.
Monitoring & Follow-up
- Track incidence of CVD and CBD in NMO patients post-diagnosis.
Risks
- Increased risk of ischemic stroke, hemorrhagic stroke, and transient ischemic attack.
Patient & Prescribing Data
1,376 patients with newly diagnosed NMO.
No specific treatment insights provided; focus on monitoring macrovascular risks.
Clinical Best Practices
- Utilize propensity score matching to control for confounding variables in observational studies.
- Ensure diagnostic validity by confirming multiple outpatient or inpatient diagnoses.
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