CCL25 chemokine promotes antiviral tissue resident CD4+ and CD8+ effector memory TRM cells associated with a reduction of ocular herpes infection and disease: a potential gut–eye axis in herpes immunity - Scorecard - MDSpire
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CCL25 chemokine promotes antiviral tissue resident CD4+ and CD8+ effector memory TRM cells associated with a reduction of ocular herpes infection and disease: a potential gut–eye axis in herpes immunity
Clinical Scorecard: The Role of CCL25 Chemokine in Enhancing Antiviral Tissue-Resident CD4+ and CD8+ Effector Memory TRM Cells Linked to Decreased Ocular Herpes Infection and Disease: Insights into the Gut–Eye Axis in Herpes Immunity
At a Glance
Category
Detail
Condition
Ocular Herpes Infection
Key Mechanisms
CCL25 chemokine enhances recruitment of antiviral effector memory T cells to the cornea.
Target Population
Individuals at risk of HSV-1 infection and recurrent herpetic keratitis.
Care Setting
Immunological research and ocular disease management.
Key Highlights
CCL25 deficiency leads to increased severity of corneal disease and viral replication.
Reduced survival observed in CCL25-deficient mice infected with HSV-1.
CCL25 supports recruitment of CD4+ and CD8+ tissue-resident memory T cells.
Mucosal chemokines CXCL14, CXCL17, and CCL28 are upregulated in wild-type mice during infection.
The study supports the concept of a gut-eye axis in herpes immunity.
Guideline-Based Recommendations
Diagnosis
Assess corneal disease severity and viral replication in HSV-1 infections.
Management
Consider targeting CCL25/CCR9 pathways for ocular immunotherapy.
Monitoring & Follow-up
Monitor levels of antiviral effector memory T cells in ocular tissues.
Risks
Increased risk of severe corneal disease and vision loss in CCL25-deficient individuals.
Patient & Prescribing Data
Patients with HSV-1 infection and recurrent herpetic keratitis.
Potential for CCL25-targeted therapies to enhance ocular immunity.
Clinical Best Practices
Evaluate the role of mucosal chemokines in ocular immunity.
Incorporate immunological assessments in managing HSV-1 infections.
Investigate the gut-eye axis in patients with recurrent herpetic keratitis.
by Azizur Rahman, Swayam Prakash, Sweta Karan, Sarah Xue Le Ng, Gina Park, Chhaya Maurya, America Garcia, Khan Intharachalit, Junseong Hwang, Celine Tze Yao Tang, Reilly Andrew Chow, Baverly Sabathini Suoth, Emma Jane Liao, Lbachir BenMohamed
