Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways
-
By
-
M. C. Gronske
-
W. Stutts
-
D. Jima
-
J. Palumbo
-
H. M. Stapleton
-
S. W. Kullman
-
June 2, 2026
-
Clinical Scorecard: Triphenyl Phosphate Induces Lipid Accumulation in Human Mesenchymal Stem Cells via Metabolic Stress Mechanisms
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | Humans, particularly children and individuals exposed to environmental contaminants (specify age range if possible). |
| Care Setting | |
Key Highlights
- Triphenyl Phosphate (TPhP) is a prevalent organophosphate flame retardant linked to various health issues.
- TPhP exposure is associated with lipid accumulation in human mesenchymal stem cells.
- Environmental exposure to TPhP occurs through multiple routes, including diet and inhalation.
- TPhP functions as a PPARy agonist, promoting differentiation into adipogenic lineages.
Guideline-Based Recommendations
Diagnosis
- Monitor exposure levels to organophosphate esters in at-risk populations.
Management
- Implement strategies to reduce exposure to TPhP and similar compounds.
Monitoring & Follow-up
- Assess metabolic health and lipid profiles in individuals with known exposure.
Risks
- Potential for neurotoxicity, developmental toxicity, and metabolic disorders.
Patient & Prescribing Data
Individuals exposed to environmental contaminants, particularly children.
Monitor metabolic health.
Clinical Best Practices
- Educate patients about potential sources of organophosphate exposure.
- Encourage lifestyle modifications to mitigate obesity risk.
Related Resources & Content
