Impact of Aerobic versus Resistance Training on Sleep Quality and Cancer-Related Fatigue in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Three-Arm Randomized Controlled Study - Scorecard - MDSpire

Impact of Aerobic versus Resistance Training on Sleep Quality and Cancer-Related Fatigue in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Three-Arm Randomized Controlled Study

  • By

  • Alexander Haussmann

  • Martina E. Schmidt

  • Siri Goldschmidt

  • Anouk E. Hiensch

  • Joachim Wiskemann

  • Karen Steindorf

  • January 28, 2026

  • 0 min

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Clinical Scorecard: Impact of Aerobic versus Resistance Training on Sleep Quality and Cancer-Related Fatigue in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Three-Arm Randomized Controlled Study

At a Glance

CategoryDetail
ConditionBreast Cancer
Key MechanismsNeoadjuvant chemotherapy (NACT) impacts cancer-related fatigue (CRF) and sleep quality.
Target PopulationAdult female patients with breast cancer scheduled for NACT.
Care SettingOncology training facilities, supervised by trained personnel.

Key Highlights

  • Breast cancer accounts for 23.8% of all cancer cases globally.
  • NACT is widely accepted for tumor shrinkage prior to surgery.
  • Exercise interventions may alleviate CRF and improve sleep quality during NACT.
  • ACSM recommends at least 30 minutes of moderate-intensity aerobic exercise three times per week.
  • Limited evidence exists on the effects of exercise during NACT specifically.

Guideline-Based Recommendations

Diagnosis

  • Patients should be evaluated for CRF and sleep disturbances during NACT.

Management

  • Implement aerobic or resistance training interventions during NACT.

Monitoring & Follow-up

  • Assess CRF and sleep quality at multiple time points during and after NACT.

Risks

  • Patients with contraindications for exercise should be excluded from interventions.

Patient & Prescribing Data

Adult female patients with breast cancer undergoing NACT.

Exercise interventions can be initiated before surgery to improve outcomes.

Clinical Best Practices

  • Supervise exercise interventions with trained personnel.
  • Provide standardized instructions for exercise performance.
  • Encourage participation in small group settings for support.

References

Original Source(s)

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