Adverse outcomes for autistic people: an umbrella review of mental health, physical health, social and lifestyle domains
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By
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Blandine French
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Victoria Newell
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Gamze Nalbant
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Hannah Wright
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David Daley
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Sarah Cassidy
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May 11, 2026
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Clinical Scorecard: Negative Outcomes in Autism: A Comprehensive Review of Mental, Physical, Social, and Lifestyle Health Factors
At a Glance
| Category | Detail |
|---|
| Condition | Autism Spectrum Disorder |
| Key Mechanisms | Increased risk of adverse outcomes across mental, physical, and social domains. |
| Target Population | Individuals with autism across the lifespan. |
| Care Setting | Healthcare, education, social care, employment, and justice contexts. |
Key Highlights
- Autistic individuals face heightened risks of anxiety, mood disorders, and suicidality.
- Common physical health issues include obesity, epilepsy, and gastrointestinal problems.
- Social challenges encompass victimization, bullying, and unemployment.
- Quality of life is significantly reduced among autistic individuals.
- Adverse outcomes are interconnected across multiple life domains.
Guideline-Based Recommendations
Diagnosis
- Utilize comprehensive assessments to identify co-occurring conditions.
Management
- Implement holistic support strategies addressing mental, physical, and social health.
Monitoring & Follow-up
- Regularly assess mental health and social functioning in autistic individuals.
Risks
- Be aware of increased risks for self-harm, substance abuse, and mortality.
Patient & Prescribing Data
Individuals diagnosed with autism spectrum disorder.
Focus on integrated care approaches to address multifaceted needs.
Clinical Best Practices
- Adopt a multidisciplinary approach to care.
- Encourage social skills training and mental health support.
- Facilitate access to educational and employment resources.
Related Resources & Content
