A novel ventricular septal reconstruction device for post-myocardial infarction ventricular septal rupture: preclinical and first-in-human study results - Scorecard - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Innovative Device for Ventricular Septal Reconstruction Following Post-Myocardial Infarction Rupture: Findings from Preclinical and Initial Human Trials

  • By

  • Changjing Huang

  • Nan Cai

  • Youqian Li

  • Yao Yao

  • Zexun Zhu

  • Weike Wu

  • Kaibing Ren

  • Siwei Wu

  • Jingfeng Liu

  • Jingyuan Hou

  • Haifeng Hong

  • Hanlin Li

  • Zhihui Hu

  • Zhixiong Zhong

  • Wei Zhong

  • September 9, 2026

Share

Clinical Scorecard: Innovative Device for Ventricular Septal Reconstruction Following Post-Myocardial Infarction Rupture: Findings from Preclinical and Initial Human Trials

At a Glance

CategoryDetail
ConditionPost-myocardial infarction ventricular septal rupture (PIVSR)
Key MechanismsUtilization of a dedicated Ventricular Septal Reconstruction Device (VSRD) designed for effective closure of PIVSR.
Target PopulationPatients with post-myocardial infarction ventricular septal rupture, particularly those at high surgical risk.
Care SettingPreclinical animal studies and first-in-human clinical trials.

Key Highlights

  • PIVSR has a poor prognosis with survival rates of 6% at 1 month and below 3% at 1 year with pharmacotherapy.
  • The VSRD showed procedural feasibility and acceptable short-term safety in both animal and human studies.
  • Residual shunts remained ≤2 mm in all four patients during follow-up after VSRD implantation.
  • No structural device malfunction or delivery-system failure was documented in animal studies.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis of PIVSR should be confirmed through imaging techniques such as echocardiography and angiography.

Management

  • Consideration of transcatheter closure with VSRD for patients unsuitable for surgery or with complex defects.

Monitoring & Follow-up

  • Follow-up assessments should include echocardiography to evaluate residual shunts and tissue response.

Risks

  • High mortality associated with surgical intervention and potential complications from existing treatment options.

Patient & Prescribing Data

Patients with PIVSR, particularly those at high surgical risk or with unsuitable anatomy for conventional devices.

The VSRD may offer a less invasive alternative to traditional surgical repair methods.

Clinical Best Practices

  • Utilize imaging guidance for device placement in PIVSR cases.
  • Monitor for residual shunts and adverse events post-implantation.

Related Resources & Content

Original Source(s)

A novel ventricular septal reconstruction device for post-myocardial infarction ventricular septal rupture: preclinical and first-in-human study results

  • by Changjing Huang, Nan Cai, Youqian Li, Yao Yao, Zexun Zhu, Weike Wu, Kaibing Ren, Siwei Wu, Jingfeng Liu, Jingyuan Hou, Haifeng Hong, Hanlin Li, Zhihui Hu, Zhixiong Zhong, Wei Zhong

  • September 9, 2026

Related Content

CKM staging faces an early vascular test

Investigators examined Life’s Essential 8 scores and carotid ultrasonography measures across cardiovascular-kidney-metabolic stages in 1,283 young adults.

Enterovirus diversity may limit treatment advances

Research highlights expanding diagnostic capabilities but persistent gaps in antiviral therapy and vaccine coverage for pediatric enterovirus infections.

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk