Mpox Sequelae Persist 11 to 18 Months After Infection
Study supports follow-up and multidisciplinary care for persistent physical and psychosocial effects
By
Henry Thomas
January 27, 2026
Clinical Scorecard: Mpox Sequelae Persist 11 to 18 Months After Infection
At a Glance
Category Detail
Condition Mpox sequelae Key Mechanisms Persistent physical and psychosocial effects following acute mpox infection. Target Population Adults with prior laboratory-confirmed mpox. Care Setting Post-acute care and follow-up clinics.
Key Highlights
58% of participants had at least one persistent sequela. Most common sequelae included skin discoloration and scarring. 13% reported functional complications, mainly anorectal and urinary symptoms. 45% experienced increased depressive symptoms. Persistent sequelae linked to more severe acute disease. Guideline-Based Recommendations
Diagnosis
Assess for persistent physical sequelae and psychosocial effects in post-mpox patients. Management
Provide support for ongoing social and sexual health challenges. Monitoring & Follow-up
Long-term follow-up for skin changes and functional symptoms. Risks
Higher likelihood of social and sexual performance issues in patients with functional sequelae. Patient & Prescribing Data
Adults previously diagnosed with mpox.
Persistent sequelae not linked to HIV control, vaccination, or antiviral treatment.
Clinical Best Practices
Conduct thorough assessments for psychosocial impacts post-mpox. Monitor for functional complications and provide necessary interventions. Encourage reporting of ongoing symptoms to guide management. Related Resources & Content
