Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection - Scorecard - MDSpire

Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection

  • By

  • Valentina Artusa

  • Roberta Zamarato

  • Lara De Luca

  • Livia Benedetti

  • Mirko Compagno

  • Mario Alberto Cano Fiestas

  • Diego Bottan

  • Mario Clerici

  • Mara Biasin

  • Daria Trabattoni

  • the MARISA Study Group

  • July 15, 2026

Share

Clinical Scorecard: Immune Signatures in Mucosal and Systemic Compartments Indicate Compartmentalized Control of Gut Barrier Function in HIV-Infected Individuals with Virological Suppression

At a Glance

CategoryDetail
ConditionHIV Infection
Key MechanismsPersistent immune activation and inflammation affecting gut barrier function despite virological suppression.
Target PopulationPeople living with HIV (PLWH) who are virologically suppressed.
Care SettingClinical research on immune and mucosal health in HIV.

Key Highlights

  • Distinct mucosal transcriptional patterns reflect disease stage, ART regimen and immune recovery.
  • INSTI-based therapy drives epithelial junctional remodelling toward improved barrier integrity.
  • Coordinated but spatially restricted epithelial–immune regulation in treated HIV.

Guideline-Based Recommendations

Diagnosis

  • Assessment of mucosal and peripheral immune signatures in HIV-infected individuals.

Management

  • Consideration of ART regimen effects on mucosal health and immune recovery.

Monitoring & Follow-up

  • Monitoring of plasma biomarkers of epithelial injury and systemic inflammation.

Risks

  • Ongoing barrier dysfunction associated with non-AIDS comorbidities.

Patient & Prescribing Data

Virologically suppressed individuals on ART.

ART does not fully restore mucosal immunity or reverse intestinal barrier dysfunction.

Clinical Best Practices

  • Direct mucosal assessment to evaluate residual immune perturbations.
  • Focus on improving mucosal barrier integrity in treatment strategies.

Related Resources & Content

    Original Source(s)

    Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection

    • by Valentina Artusa, Roberta Zamarato, Lara De Luca, Livia Benedetti, Mirko Compagno, Mario Alberto Cano Fiestas, Diego Bottan, Mario Clerici, Mara Biasin, Daria Trabattoni, the MARISA Study Group

    • July 15, 2026

    Related Content

    Is hidradenitis suppurativa more an autoinfection than pure autoinflammation?

    Preoperative gut microbiota depletion and metabolomic signatures predict postoperative pneumonia in patients with intracranial space-occupying lesions: a multi-omics prospective cohort study

    Mass Spec Roundup: Protein Stress, Cannabis Chemistry and Sharks… 

    From T cell dysfunction to shark vertebrae, mass spectrometry traces hidden chemistry across cells, crops, foods, and river systems 

    • May 6, 2026

    • 7 min